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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR1A
All Species:
31.82
Human Site:
Y185
Identified Species:
50
UniProt:
P10644
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10644
NP_002725.1
381
42982
Y185
D
Q
G
E
T
D
V
Y
V
N
N
E
W
A
T
Chimpanzee
Pan troglodytes
XP_511647
260
29299
G93
P
P
N
P
V
V
K
G
R
R
R
R
G
A
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537577
381
43019
Y185
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBC7
381
43167
Y185
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
Rat
Rattus norvegicus
P09456
381
43076
Y185
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509586
626
69567
Y430
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
Chicken
Gallus gallus
Q5ZM91
382
43332
Y186
D
Q
G
E
M
D
V
Y
V
N
N
E
W
A
T
Frog
Xenopus laevis
NP_001085084
381
43157
Y185
D
Q
G
E
M
D
V
Y
V
N
N
E
W
M
T
Zebra Danio
Brachydanio rerio
NP_001017732
379
43009
Y183
D
Q
G
E
M
D
V
Y
V
N
S
E
W
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16905
376
42221
F180
D
V
G
E
V
D
V
F
V
N
S
E
L
V
T
Honey Bee
Apis mellifera
XP_396167
372
41646
E193
G
E
G
G
S
F
G
E
L
A
L
I
Y
G
T
Nematode Worm
Caenorhab. elegans
P30625
366
41449
G182
Y
V
L
T
I
N
E
G
G
S
F
G
E
L
A
Sea Urchin
Strong. purpuratus
Q26619
369
41770
M190
S
F
G
E
L
A
L
M
Y
N
T
P
R
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
Y232
E
K
G
T
V
D
F
Y
V
N
D
N
K
V
N
Red Bread Mold
Neurospora crassa
Q01386
385
42138
G191
A
L
Q
P
G
P
D
G
M
G
Q
K
V
G
E
Conservation
Percent
Protein Identity:
100
68.2
N.A.
97.9
N.A.
96.8
97.3
N.A.
58.7
92.4
92.6
91.5
N.A.
71.3
74
57.7
39.3
Protein Similarity:
100
68.2
N.A.
98.1
N.A.
97.3
98.4
N.A.
60
96
95.8
95.8
N.A.
81.6
85.3
73.4
56.9
P-Site Identity:
100
6.6
N.A.
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
86.6
86.6
N.A.
60
13.3
0
26.6
P-Site Similarity:
100
6.6
N.A.
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
86.6
93.3
N.A.
73.3
40
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
34
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.7
52.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
0
0
7
0
0
0
60
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
0
0
0
0
67
7
0
0
0
7
0
0
0
0
% D
% Glu:
7
7
0
67
0
0
7
7
0
0
0
60
7
0
7
% E
% Phe:
0
7
0
0
0
7
7
7
0
0
7
0
0
0
0
% F
% Gly:
7
0
80
7
7
0
7
20
7
7
0
7
7
14
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
7
% I
% Lys:
0
7
0
0
0
0
7
0
0
0
0
7
7
0
0
% K
% Leu:
0
7
7
0
7
0
7
0
7
0
7
0
7
7
0
% L
% Met:
0
0
0
0
47
0
0
7
7
0
0
0
0
7
0
% M
% Asn:
0
0
7
0
0
7
0
0
0
74
47
7
0
0
7
% N
% Pro:
7
7
0
14
0
7
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
54
7
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
7
7
7
7
7
0
0
% R
% Ser:
7
0
0
0
7
0
0
0
0
7
14
0
0
0
0
% S
% Thr:
0
0
0
14
7
0
0
0
0
0
7
0
0
0
67
% T
% Val:
0
14
0
0
20
7
60
0
67
0
0
0
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
54
0
0
% W
% Tyr:
7
0
0
0
0
0
0
60
7
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _